This collection of David Lynch's short films cover the first 29 years of his career. Each film is given a special introduction by the director himself. His earliest underground films Six Figures Getting Sick (1966), The Alphabet (1968), The Grandmother (1970) and The Amputee (1974) are showcased as well as two requisitioned works well into his successful career The Cowboy and the Frenchman (1988) and his addition for Lumière and Company (1995).

Against a backdrop of bizarre shapes and textures, a small organic figure gives birth to the letters of the alphabet while a mixture of children's voices and an operatic tune are singing out. The figure's head collapses causing blood to rain on a girl while she lays in her bed, resulting in the girl violently vomiting blood herself.